3DCoffee@igs: a web server for combining sequences and structures into a multiple sequence alignment

Title3DCoffee@igs: a web server for combining sequences and structures into a multiple sequence alignment
Publication TypeJournal Article
Year of Publication2004
AuthorsPoirot O, Suhre K, Abergel C, O'Toole E, Notredame C
JournalNucleic Acids Res
Volume32
PaginationW37-40
Date PublishedJul 1
Accession Number15215345
KeywordsInternet, Proteins/chemistry, Sequence Alignment, Sequence Analysis, Protein, Software
Abstract

This paper presents 3DCoffee@igs, a web-based tool dedicated to the computation of high-quality multiple sequence alignments (MSAs). 3D-Coffee makes it possible to mix protein sequences and structures in order to increase the accuracy of the alignments. Structures can be either provided as PDB identifiers or directly uploaded into the server. Given a set of sequences and structures, pairs of structures are aligned with SAP while sequence-structure pairs are aligned with Fugue. The resulting collection of pairwise alignments is then combined into an MSA with the T-Coffee algorithm. The server and its documentation are available from http://igs-server.cnrs-mrs.fr/Tcoffee/.