Accurate multiple sequence alignment of transmembrane proteins with PSI-Coffee.
|Title||Accurate multiple sequence alignment of transmembrane proteins with PSI-Coffee.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Chang JM, Di Tommaso P, Taly JF, Notredame C|
|Volume||13 Suppl 4|
Transmembrane proteins (TMPs) constitute about 20 30% of all protein coding genes. The relative lack of experimental structure has so far made it hard to develop specific alignment methods and the current state of the art (PRALINE™) only manages to recapitulate 50% of the positions in the reference alignments available from the BAliBASE2-ref7.