Are splicing mutations the most frequent cause of hereditary disease?

TitleAre splicing mutations the most frequent cause of hereditary disease?
Publication TypeJournal Article
Year of Publication2005
AuthorsLópez-Bigas N, Audit B, Ouzounis C, Parra G, Guigó R
JournalFEBS Lett.
Volume579
Pagination1900–1903
Date PublishedMar
Abstract

Disease-causing point mutations are assumed to act predominantly through subsequent individual changes in the amino acid sequence that impair the normal function of proteins. However, point mutations can have a more dramatic effect by altering the splicing pattern of the gene. Here, we describe an approach to estimate the overall importance of splicing mutations. This approach takes into account the complete set of genes known to be involved in disease and suggest that, contrary to current assumptions, many mutations causing disease may actually be affecting the splicing pattern of the genes.

URLhttp://dx.doi.org/10.1016/j.febslet.2005.02.04
DOI10.1016/j.febslet.2005.02.047