Characterization of mammalian selenoproteomes.

TitleCharacterization of mammalian selenoproteomes.
Publication TypeJournal Article
Year of Publication2003
AuthorsKryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN
JournalScience
Volume300
Pagination1439–1443
Date PublishedMay
Abstract

In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons, and the presence of cysteine-containing homologs. The human selenoproteome consists of 25 selenoproteins.

URLhttp://dx.doi.org/300/5624/143
DOI300/5624/1439