Computing multiple sequence/structure alignments with the T-coffee package.
|Title||Computing multiple sequence/structure alignments with the T-coffee package.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Journal||Curr Protoc Bioinformatics|
|Pagination||Unit 3.8.1–Unit 3.825|
In this unit, we describe assembly of a multiple sequence alignment using the T-Coffee package. T-Coffee is much more flexible than most related methods (e.g., ClustalW) because it makes it possible to combine many alternative alignments into a single one, based on an estimate of consistency between these alignments. This strategy can be especially useful when one has to decide among the output produced by several alternative methods.