Metastability of Native Proteins and the Phenomenon of Amyloid Formation.

TitleMetastability of Native Proteins and the Phenomenon of Amyloid Formation.
Publication TypeJournal Article
Year of Publication2011
AuthorsBaldwin AJ, Knowles TP, Tartaglia G, Fitzpatrick A, Devlin G, Shammas S, Waudby CA, Mossuto MF, Gras SL, Christodoulou J, Anthony-Cahill SJ, Barker PD, Vendruscolo M, Dobson CM
JournalJournal of the American Chemical Society
Date PublishedJun
Abstract

An experimental determination of the thermodynamic stabilities of a series of amyloid fibrils reveals that this structural form is likely to be the most stable one that protein molecules can adopt even under physiological conditions. This result challenges the conventional assumption that functional forms of proteins correspond to the global minima in the free energy surfaces and suggests that living systems are conformationally as well as chemically metastable.

URLhttp://dx.doi.org/10.1021/ja2017703
DOI10.1021/ja2017703