Nested genes and increasing organizational complexity of metazoan genomes.

TitleNested genes and increasing organizational complexity of metazoan genomes.
Publication TypeMiscellaneous Section
Year of Publication2008
AuthorsAssis R, Kondrashov AS, Koonin EV, Kondrashov FA
Abstract

The most common form of protein-coding gene overlap in eukaryotes is a simple nested structure, whereby one gene is embedded in an intron of another. Analysis of nested protein-coding genes in vertebrates, fruit flies and nematodes revealed substantially higher rates of evolutionary gains than losses. The accumulation of nested gene structures could not be attributed to any obvious functional relationships between the genes involved and represents an increase of the organizational complexity of animal genomes via a neutral process.

URLhttp://dx.doi.org/10.1016/j.tig.2008.08.003
DOI10.1016/j.tig.2008.08.003