Predicting phenotypic traits of prokaryotes from protein domain frequencies.

TitlePredicting phenotypic traits of prokaryotes from protein domain frequencies.
Publication TypeJournal Article
Year of Publication2010
AuthorsLingner T, Mühlhausen S, Gabaldón T, Notredame C, Meinicke P
JournalBMC Bioinformatics
Volume11
Pagination481
Abstract

Establishing the relationship between an organism's genome sequence and its phenotype is a fundamental challenge that remains largely unsolved. Accurately predicting microbial phenotypes solely based on genomic features will allow us to infer relevant phenotypic characteristics when the availability of a genome sequence precedes experimental characterization, a scenario that is favored by the advent of novel high-throughput and single cell sequencing techniques.

URLhttp://dx.doi.org/10.1186/1471-2105-11-481
DOI10.1186/1471-2105-11-481