Predicting phenotypic traits of prokaryotes from protein domain frequencies.
|Title||Predicting phenotypic traits of prokaryotes from protein domain frequencies.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Lingner T, Mühlhausen S, Gabaldón T, Notredame C, Meinicke P|
Establishing the relationship between an organism's genome sequence and its phenotype is a fundamental challenge that remains largely unsolved. Accurately predicting microbial phenotypes solely based on genomic features will allow us to infer relevant phenotypic characteristics when the availability of a genome sequence precedes experimental characterization, a scenario that is favored by the advent of novel high-throughput and single cell sequencing techniques.