Prediction of local structural stabilities of proteins from their amino acid sequences.

TitlePrediction of local structural stabilities of proteins from their amino acid sequences.
Publication TypeJournal Article
Year of Publication2007
AuthorsTartaglia GG, Cavalli A, Vendruscolo M
JournalStructure
Volume15
Pagination139–143
Date PublishedFeb
Abstract

Hydrogen exchange experiments provide detailed information about the local stability and the solvent accessibility of different regions of the structures of folded proteins, protein complexes, and amyloid fibrils. We introduce an approach to predict protection factors from hydrogen exchange in proteins based on the knowledge of their amino acid sequences without the inclusion of any additional structural information. These results suggest that the propensity of different regions of the structures of globular proteins to undergo local unfolding events can be predicted from their amino acid sequences with an accuracy of 80% or better.

URLhttp://dx.doi.org/10.1016/j.str.2006.12.007
DOI10.1016/j.str.2006.12.007