Selection for Functional Uniformity of tuf Duplicates in Gamma-proteobacteria

TitleSelection for Functional Uniformity of tuf Duplicates in Gamma-proteobacteria
Publication TypeJournal Article
Year of Publication2007
AuthorsKondrashov FA, Gurbich TA, Vlasov PK
JournalTrends Genet
Volume23
Pagination215-218
Abstract

Having an extra copy of a gene is thought to provide some functional redundancy, which results in a higher rate of evolution in duplicated genes. In this article, we estimate the impact of gene duplication on the selection of tuf paralogs, and we find that in the absence of gene conversion, tuf paralogs have evolved significantly slower than when gene conversion has been a factor in their evolution. Thus, tuf gene copies evolve under a selective pressure that ensures their functional uniformity, and gene conversion reduces selection against amino acid substitutions that affect the function of the encoded protein, EF-Tu.