Tcoffee@igs: A web server for computing, evaluating and combining multiple sequence alignments

TitleTcoffee@igs: A web server for computing, evaluating and combining multiple sequence alignments
Publication TypeJournal Article
Year of Publication2003
AuthorsPoirot O, O'Toole E, Notredame C
JournalNucleic Acids Res
Volume31
Pagination3503-6
Date PublishedJul 1
Accession Number12824354
KeywordsConsensus Sequence, Internet, Phylogeny, Sequence Alignment/ methods, Sequence Analysis, DNA/methods, Sequence Analysis, Protein/methods, Sequence Analysis, RNA/methods, Software
Abstract

This paper presents Tcoffee@igs, a new server provided to the community by Hewlet Packard computers and the Centre National de la Recherche Scientifique. This server is a web-based tool dedicated to the computation, the evaluation and the combination of multiple sequence alignments. It uses the latest version of the T-Coffee package. Given a set of unaligned sequences, the server returns an evaluated multiple sequence alignment and the associated phylogenetic tree. This server also makes it possible to evaluate the local reliability of an existing alignment and to combine several alternative multiple alignments into a single new one. Tcoffee@igs can be used for aligning protein, RNA or DNA sequences. Datasets of up to 100 sequences (2000 residues long) can be processed. The server and its documentation are available from: http://igs-server.cnrs-mrs.fr/Tcoffee/.