Gene Function and Evolution

Group leader:  Gian Gaetano Tartaglia
Predictions of Interactomes and Evolution of Proteomes

 

PhylomeDB V4 released

The new version of PhylomeDB has been released. Version 4  

MetaPhOrs: orthologs and paralogs accross 829 genomes, based on multiple phylogenetic evidence

We have launched MetaPhOrs, a meta-method to predict orthology and paralogy from multiple phylogenetic evidence. To maximize reliability and coverage, we retrieved gene trees from PhylomeDB, Ensembl, TreeFam and Orthogroups. In addition we built maximum likelihood trees for orthologous gene families in OrthoMCL, COG, and EggNOG.

Bibliography

PhylomeDB v3.0 released

A new version of PhylomeDB has been released. With over 400.000 phylogenetic trees, PhylomeDB is currently the major public phylogenetic repository. It contains phylomes from model (Human, Yeast, Drosophila, Arabidopsis), but also alternative models such as the fungal pathogen Candida albicans, or the insects T. castaneum, N. vitripenis  and A. pisum.  New features have been added to the user's front end, including fully interactive tree images and link outs to external information.

Bibliography

Nothing found

New trends in protein sequence divergence

In an article published online in Nature, we validated the hypothesis that compensatory interactions allow most protein sequences, even the most conservative ones, to maintain the same function while diverging in sequence almost without limit.

 

 

Syndicate content