SymCurv

SymCurv is a computational ab initio method for nucleosome positioning prediction. It is based on the structural property of natural nucleosome forming sequences, to be symmetrically curved around a local minimum of curvature. The method takes as input the primary DNA sequence, calculates the expected curvature from which it deduces possible centers of nucleosomal sequences, by imposing symmetry constraints. SymCurv's performance is comparable to existing tools but offers the additional advantages of predicting nucleosome positions under two assumed-states (stationary and dynamic) providing insight on the remodelling potential of nucleosomes of possible regulatory function.