Identification of genetic variants associated with alternative splicing using sQTLseekeR

Nature Communications article here.

The latest version as well as more details on installation and usage can be found on sQTLseekeR github page.


New in sQTLseekeR 2.0 (2014-10-14) : New packaging available and maintained on GitHub.

Development of methods to analyze the relationship between chromatin and splicing

The search of sequence prerequisites for nucleosome positioning has been a long-standing problem at the intersection of chromatin structure and gene regulation. With the use of structural information directly related to the primary DNA sequence we propose a new property of natural nucleosome forming sequences, which is inherently related to their intrinsic curvature and its symmetry.

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